Electroresponsive Thiol–Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control

• DOI: 10.1021/acsapm.4c00911
• Publication Date: 2024-07-11T17:35:19Z
• Authors: Helena Muñoz-Galán; Hamidreza Enshaei; João C. Silva; Teresa Esteves; Frederico Castelo...; Jordi Casanovas; Joshua C. Worch; Andrew P. Dove; Carlos Alemán; Maria M. Pérez-Ma...
• Keywords: Leakage (economics); Thiol; Insulin delivery

Diabetes is a metabolic disorder caused by the body's inability to produce or use insulin. Considering figures projected World Health Organization, research on insulin therapy crucial. Hence, we present soft biointerface based thiol-yne poly(ethylene glycol) (PEG) click-hydrogel as an advanced treatment option administrate Most importantly, device rendered electroactive incorporating biocompatible poly(3,4-ethylenedioxythiophene) nanoparticles (PEDOT NPs) conductive moieties precisely control release of over extended period through electrochemical stimulation (ES). The has been carefully optimized account of: (i) main interactions established between PEDOT- and PEG-based moieties, which have studied density functional theory calculations, reveal choice 4-arm PEG precursors most suitable cross-linkers; (ii) concentration PEDOT NPs in device, determined considering minimal interference with gelation process, well resulting morphological, mechanical, electrochemical, cytocompatible properties click-hydrogels. Finally, management delivery ES verified vitro, released being detected high-performance liquid chromatography. Overall, our hydrogel-based establishes method for controlled potential translation other relevant bioelectronic applications.