Hybrid Composite of Silver Nanoparticle–Porous Silicon Microparticles as an Image-Guided Localization Agent for Computed Tomography Scan of the Lungs

• DOI: 10.1021/acsbiomaterials.0c00611
• Publication Date: 2020-06-25T02:17:52Z
• Authors: Eun Mi Lee; Jiyeon Lee; Yejin Kim; Kyung Sik Yi; Janggeun Cho; Jaehoon Kim; Jong Min An; Dahae Lee; Sung Joon Kim; Eunkyung An; Yoo Jin Hong; Hyejung Jo; Seo Hyeon Lee; Yuna Jung; Chi-Hoon Choi; Jae Seung Kang; Jin Hur; Dokyoung Kim
• Keywords: Porous Silicon; Silver nanoparticle

A hybrid composite of silver nanoparticles (AgNPs) and porous silicon microparticles (pSiMPs) was developed applied for the computed tomography (CT) scanning lungs as an image-guided localization agent. We confirmed grafting AgNPs on oxidized pSiMPs template using various analytical equipment, including a electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), energy-dispersive spectroscopy (EDS). The showed high CT contrast intensity (>1000 HU) that enabled us to produce view images lungs. In addition, it ability maintain strong signal at injected area rabbit's lungs, up hour, without spreading. lack toxicity immune response indicated could be fully utilized new agent scans lung cancer surgery.