Sr-Incorporated Bioactive Glass Remodels the Immunological Microenvironment by Enhancing the Mitochondrial Function of Macrophage via the PI3K/AKT/mTOR Signaling Pathway

• DOI: 10.1021/acsbiomaterials.4c00228
• Publication Date: 2024-05-20T08:38:33Z
• Authors: Huanhuan Qiu; Huacui Xiong; Jiafu Zheng; Yuqi Peng; Chunhui Wang; Qing Hu; Fujian Zhao; Ke Chen
• Keywords: Macrophage polarization

The repair of critical-sized bone defects continues to pose a challenge in clinics. Strontium (Sr), recognized for its function metabolism regulation, has shown potential repair. However, the underlying mechanism through which Sr2+ guided favorable osteogenesis by modulating macrophages remains unclear, limiting their application design biomaterials. Herein, Sr-incorporated bioactive glass (SrBG) was synthesized further investigation. release Sr ions enhanced immunomodulatory properties and osteogenic polarization toward M2 phenotype. In vivo, 3D-printed SrBG scaffold fabricated showed consistently improved regeneration creating prohealing immunological microenvironment. RNA sequencing performed explore mechanisms. It found that might enhance mitochondrial macrophage activating PI3K/AKT/mTOR signaling, thereby favoring osteogenesis. Our findings demonstrate relationship between role macrophages. By focusing on macrophages, Sr2+-mediated immunomodulation sheds light future biomaterials tissue regenerative engineering.