Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood–Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson’s Disease

• DOI: 10.1021/acschemneuro.6b00207
• Publication Date: 2016-09-19T14:44:13Z
• Authors: Paromita Kundu; Manasi Das; Kalpalata Tripathy; Sanjeeb K Sahoo
• Keywords: Rotenone

Parkinson's disease (PD) is the most widespread form of dementia where there an age related degeneration dopaminergic neurons in substantia nigra region brain. Accumulation α-synuclein (αS) protein aggregate, mitochondrial dysfunction, oxidative stress, and neuronal cell death are pathological hallmarks PD. In this context, amalgamation curcumin piperine having profound cognitive properties, antioxidant activity seems beneficial. However, blood–brain barrier (BBB) major impediment for delivery neurotherapeutics to The present study involves formulation coloaded glyceryl monooleate (GMO) nanoparticles coated with various surfactants a view enhance bioavailability penetration both drugs brain tissue crossing BBB anti-parkinsonism effect single platform. vitro results demonstrated augmented inhibition αS into oligomers fibrils, reduced rotenone induced toxicity, apoptosis, activation autophagic pathway by dual drug loaded NPs compared native counterpart. Further, vivo studies revealed that our formulated were able cross BBB, rescued motor coordination impairment, restrained PD mouse model.