Microwave-Assisted Regioselective Synthesis of 3-Functionalized Indole Derivatives via Three-Component Domino Reaction

• DOI: 10.1021/acscombsci.7b00126
• Publication Date: 2017-10-06T20:18:17Z
• Authors: Wei Lin; Yong-Xiang Zheng; Zhan Xun; Zhi-Bin Huang; Da-Qing Shi
• Keywords: Aniline Compounds; Indoles; Combinatorial Chemistry Techniques; Chemistry Techniques, Synthetic; Glyoxal; Microwaves; 01 natural sciences; 0104 chemical sciences

A microwave-assisted regioselective synthesis of 3-functionalized indole derivatives via a three-component domino reaction of anilines, arylglyoxal monohydrates, and cyclic 1,3-dicarbonyl compounds is described. The main advantages of this protocol are short reaction times, practical simplicity, its metal-free nature, the availability of starting materials, green solvents, and high regioselectivity.