Alanyl-Glutamine (Ala-Gln) Ameliorates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by Regulating the Gut Microbiota, PI3K-Akt/NF-κB/STAT3 Signaling, and Associated Pulmonary Injury

• DOI: 10.1021/acsinfecdis.3c00014
• Publication Date: 2023-03-14T19:31:49Z
• Authors: Jing Liu; Chengguo Zong; Xin Yu; Yan Ding; Bing Chang; Ruoyu Wang; Lixuan Sang
• Keywords: Mice, Inbred C57BL; Mice; Phosphatidylinositol 3-Kinases; Dextran Sulfate; NF-kappa B; Animals; Cytokines; Lung Injury; Colitis; Proto-Oncogene Proteins c-akt; 3. Good health; Gastrointestinal Microbiome

The aim of this study was to investigate the protective effect alanyl-glutamine (Ala-Gln) on acute colitis complicated by pulmonary injury induced dextran sulfate sodium (DSS) in C57BL/6 mice. results showed that Ala-Gln intervention alleviated weight loss, disease activity index (DAI), colon shortening, and pathological regulated absolute number CD4+T-cell subsets mesenteric lymph nodes (MLNs). In addition, significantly ameliorated composition gut microbiota mice with DSS- colitis, decreasing relative abundance Desulfovibrionaceae increasing abundances Gastranaerophilales, Clostridia-vadinBB60, Alistipes. Moreover, treatment inhibited activation PI3K-Akt/NF-κB/STAT3 inflammatory signaling pathways DSS-induced colitis. Notably, also as well imbalance levels tissue conclusion, alleviates regulating microflora pathways, alleviating accompanying injury.