The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani

• DOI: 10.1021/acsinfecdis.9b00426
• Publication Date: 2020-01-22T17:06:38Z
• Authors: Richard J. Wall; Sandra Carvalho; Rachel Milne; Juan A. Bueren-Ca...; Sonia Moniz; Juan Cantizani-Perez; Lorna MacLean; Albane Kessler; Ignacio Cotillo; Lalitha Sastry; Sujatha Manthri; Stephen Patterson; Fabio Zuccotto; Stephen Thompson; Julio Martin; Maria Marco; Timothy J. Miles; Manu De Rycker; Michael G. Thomas; Alan H. Fairlamb; Ian H. Gilbert; Susan Wyllie
• Keywords: Antiparasitic agent; Chagas Disease

Available treatments for Chagas' disease and visceral leishmaniasis are inadequate, there is a pressing need new therapeutics. Drug discovery efforts both diseases principally rely upon phenotypic screening. However, the optimization of phenotypically active compounds hindered by lack information regarding their molecular target(s). To combat this issue we initiate target deconvolution studies at an early stage. Here, describe comprehensive genetic biochemical to determine targets three unrelated compounds. All structurally diverse Q