Supramolecular Hunter Stationed on Red Blood Cells for Detoxification Based on Specific Molecular Recognition

• DOI: 10.1021/acsnano.0c01119
• Publication Date: 2020-03-23T22:49:23Z
• Authors: Chao Li; Zichen Xie; Qinjun Chen; Yujie Zhang; Yongchao Chu; Qin Guo; Wenxi Zhou; Yiwen Zhang; Peixin Liu; Hongyi Chen; Chen Jiang; Keyu Sun; Tao Sun
• Keywords: Detoxification; Antidote

Efficient removal of deadly toxicants by blood purification remains predominant in poisoning treatment. Current strategies mainly rely on absorptive scavengers that normally have no selectivity to the adsorbates, which could result poor clinical outcomes certain toxic species due passivity and inaccuracy detoxification procedure. Herein, a positive, accurate, customized strategy was proposed. Based sophisticated molecule design thoughtful structure analysis aimed toxicant paraquat, supramolecular hunter stationed red cells (RBC) is developed continuously track paraquat blood. In this construct, Janus dendrimer amphiphile (JDA) synthesized with aim facilely anchoring onto RBC membranes while bridging load antidote WP6 precisely recognize paraquat. vitro vivo results demonstrate effective toxicant-hunting harm-neutralizing capability system through guest-exchange reaction. This provides different insight designing can actively, precisely, hunt approach.