pH-Responsive On-Demand Alkaloids Release from Core–Shell ZnO@ZIF-8 Nanosphere for Synergistic Control of Bacterial Wilt Disease

• DOI: 10.1021/acsnano.1c09724
• Publication Date: 2022-02-09T07:24:58Z
• Authors: Wenlong Liang; Jingli Cheng; Jiadong Zhang; Qiuyu Xiong; Maojun Jin; Jinhao Zhao
• Keywords: Bacterial wilt; Nanocarriers; Bacterial growth

Developing an effective and safe technology to control severe bacterial diseases in agriculture has attracted significant attention. Here, ZnO nanosphere ZIF-8 are employed as core shell, respectively, then a pH-responsive core-shell nanocarrier (ZnO-Z) was prepared by situ crystal growth strategy. The bactericide berberine (Ber) further loaded form Ber-loaded ZnO-Z (Ber@ZnO-Z) for of tomato wilt disease. Results demonstrated that Ber@ZnO-Z could release Ber rapidly acidic environment, which corresponded the pH soil where disease often outbreak. In vitro experiments showed antibacterial activity about 4.5 times 1.8 higher than ZnO-Z, respectively. It because induce ROS generation, resulting DNA damage, cytoplasm leakage, membrane permeability changes so released without penetrability more easily penetrated bacteria achieve efficient synergistic bactericidal effect with carriers after combining DNA. Pot also significantly reduced severity index 45.8% on day 14 inoculation, compared 94.4% commercial aqueous solution. More importantly, did not accumulate aboveground parts plants affect plant short period. This work provides guidance soil-borne development sustainable agriculture.