Identification of Bithionol, Dichlorophen, and Miconazole as Antibacterial Agents against Acinetobacter calcoaceticus

• DOI: 10.1021/acsomega.0c03211
• Publication Date: 2020-09-08T22:09:43Z
• Authors: Tiffany H. Khaw; S.N. Michael Wong; Genevieve Herle; Jean Patrick Gonz...; Adhitya Logan; Saleem Alameh; Mikhail Martchenk...; Anastasia Levitin
• Keywords: Acinetobacter calcoaceticus; Acinetobacter baumannii

The rising prevalence of multidrug-resistant hospital-acquired infections has increased the need for new antibacterial agents. In this study, a library 1586 FDA-approved drugs was screened against A. calcoaceticus, representative Acinetobacter calcoaceticus-baumannii complex. Three compounds were found to have previously undiscovered properties calcoaceticus: antifungal Miconazole, anthelminthic Dichlorophen, and Bithionol. These three tested wide range Gram-positive Gram-negative bacteria confirmed broad-spectrum properties. Combinations these also same bacteria, two novel combination therapies with synergistic effects discovered. future, will be evaluated pathogenic using an animal model.