Gallic Acid-Modified Polyethylenimine–Polypropylene Carbonate–Polyethylenimine Nanoparticles: Synthesis, Characterization, and Anti-Periodontitis Evaluation

• DOI: 10.1021/acsomega.4c00261
• Publication Date: 2024-03-15T20:49:47Z
• Authors: Zunxuan Xie; Boyang Gao; Jinyao Liu; Jiaming He; Yuyan Liu; Fengxiang Gao
• Keywords: Polyethylenimine; Biocompatibility

The aim of the research was to develop novel gallic acid (GA)-modified amphiphilic nanoparticles polyethylenimine (PEI)–polypropylene carbonate (PPC)–PEI (PEPE) and comprehensively assess its properties as an antiperiodontitis nanoparticle targeting Toll-like receptor (TLR). first step is evaluate binding potential GA core trigger receptors TLR2 TLR4/MD2 for periodontitis using molecular docking techniques. Following this, we conducted NMR, transmission electron microscopy, dynamic light scattering analyses on synthesized PEPE nanoparticles. As final step, investigated synthetic results in vitro GA-PEPE investigation revealed that exhibits targeted complex. Furthermore, successfully developed 91.19 nm positively charged Spectroscopic analysis indicated successful synthesis GA-modified PEPE. Additionally, CCK8 demonstrated modification significantly reduced biotoxicity assessment illustrated 6.25 μM expression pro-inflammatory factors TNF-α, IL-1β, IL-6. nanoparticles, with their TLR capabilities, were found possess excellent biocompatibility properties. will provide highly innovative input into development anti-