Sex Pheromone Receptor-Derived Peptide Biosensor for Efficient Monitoring of the Cotton Bollworm Helicoverpa armigera

• DOI: 10.1021/acssensors.2c02384
• Publication Date: 2023-01-06T16:06:50Z
• Authors: Zhi Wang; Weichao Ma; Zisen Gao; Zhihan Zhao; Baojiang Du; Junqing Wei; Dun Jiang; Kuibo Lan; Ruibing Chen; Shanchun Yan; Guoxuan Qin
• Keywords: Molecular Docking Simulation; Animals; Female; Sex Attractants; Moths; Peptides; 01 natural sciences; Receptors, Pheromone; 0104 chemical sciences

The cotton bollworm, Helicoverpa armigera (H. armigera), causes damage to a wide range of cultivated crops and is one the pests with greatest economic importance for global agriculture. Currently, detection H. based on manual sampling. A low limit (LOD), convenient, real-time monitoring method urgently needed its early warning efficient management. Here, we characterized amino acid sequence in sex pheromone receptors (SPRs) recognizing components by three-dimensional (3D) modeling molecular docking. Next, receptor-derived peptides (SPRPs) were synthesized conjugated nanotubes chemical connection. modified used fabricate sensor capable gaseous compounds LOD (∼10 ppb Z11-16:Ald) selectivity, was able detect single live armigera. Furthermore, developed biosensor allowed direct release dynamics female showed that instantly reduced response light. report first demonstration biosensing detecting pheromones findings show great potential SPRP broad applications insect biology study infestation monitoring.