Super-resolution Multispectral Imaging Nanoimmunosensor for Simultaneous Detection of Diverse Early Cancer Biomarkers

• DOI: 10.1021/acssensors.4c00752
• Publication Date: 2024-07-04T03:04:35Z
• Authors: Seungah Lee; Junghwa Lee; Seong Ho Kang
• Keywords: Cancer Detection; Cancer Imaging

In medical diagnosis, relying on only one type of biomarker is insufficient to accurately identify cancer. Blood-based multicancer early detection can help more than cancer from a single blood sample. this study, super-resolution multispectral imaging nanoimmunosensor (srMINI) based three quantum dots (QDs) different color conjugated with streptavidin was developed for the simultaneous screening various biomarkers in at single-molecule level. experiment, srMINI chip used simultaneously detect key biomarkers: carcinoembryonic antigen (CEA), C-reactive protein (CRP), and alpha-fetoprotein (AFP). The exhibited 108 times higher sensitivity 0.18–0.5 ag/mL (1.1–2.6 zM) these commercial enzyme-linked immunosorbent assay kits because absence interfering signals substrate, establishing considerable potential multiplex blood. Therefore, using high diagnostic precision accuracy expected play decisive role diagnosis or community as biosensor.