Surface Plasmon Resonance Clinical Biosensors for Medical Diagnostics

• DOI: 10.1021/acssensors.6b00763
• Publication Date: 2016-12-25T02:38:45Z
• Authors: Jean-Francois Masson
• Keywords: Biomolecule

The design and application of sensors for monitoring biomolecules in clinical samples is a common goal the sensing research community. Surface plasmon resonance (SPR) other plasmonic techniques such as localized surface (LSPR) imaging SPR are reaching maturity level sufficient their samples. In recent years, first examples antibodies, proteins, enzymes, drugs, small molecules, peptides, nucleic acids biofluids collected from patients afflicted with series medical conditions (Alzheimer's, hepatitis, diabetes, leukemia, cancers prostate breast cancers, among others) demonstrate progress chemistry. This Perspective reviews current status field, showcasing early successes analysis detailing considerations regarding schemes, exposing issues biofluids, comparing ELISA, while providing an outlook challenges currently associated materials, instrumentation, microfluidics, bioreceptor selection, selection market, validation assay applying to Research opportunities proposed further advance field transition biosensors proof-of-concept stage actual applications.