Smart Sensing Based on DNA–Metal Interaction Enables a Label-Free and Resettable Security Model of Electrochemical Molecular Keypad Lock

• DOI: 10.1021/acssensors.7b00735
• Publication Date: 2017-12-18T11:02:38Z
• Authors: Yan Du; Xu Han; Chenxu Wang; Yunhui Li; Bingling Li; Hongwei Duan
• Keywords: Keypad; Lock (firearm)

Recently, molecular keypad locks have received increasing attention. As a new subgroup of smart biosensors, they show great potential for protecting information as security data processor, rather than merely recognition and quantitation. Herein, label-free electrochemically transduced Ag+ cysteine (Cys) sensors were developed. A lock model with reset function was successfully realized based on the balanced interaction metal ion its nucleic acid chemical ligands. The correct input "1-2-3" (i.e., "Ag+-Cys-cDNA") is only password such lock. Moreover, resetting process either or wrong order could be easily made by Cys, buffer, DI water treatment. Therefore, our system provides an even smarter lock, which inhibit illegal access unauthorized users, holding promise in protection at level.