Self-Calibrating On-Chip Localized Surface Plasmon Resonance Sensing for Quantitative and Multiplexed Detection of Cancer Markers in Human Serum

• DOI: 10.1021/acssensors.8b00305
• Publication Date: 2018-06-27T09:21:06Z
• Authors: Ozlem Yavas; Srdjan S. Aćimović; Jose Garcia-Guirado; Johann Berthelot; Paulina Dobosz; Vanesa Sanz; Romain Quidant
• Keywords: Point of care; Cancer Biomarkers; Microfluidic chip; Cancer Detection; Lab-on-a-Chip

The need for point-of-care devices able to detect diseases early and monitor their status, out of a lab environment, has stimulated the development compact biosensing configurations. Whereas localized surface plasmon resonance (LSPR) sensing integrated into state-of-the-art microfluidic chip stands as promising approach meet this demand, its implementation an operating platform capable quantitatively detecting set molecular biomarkers in unknown biological sample is only infancy. Here, we present on-chip LSPR sensor performing automatic, quantitative, multiplexed screening biomarkers. We demonstrate versatility by programming it quantify human serum four relevant protein markers associated with breast cancer.