Plasmonic Paper Microneedle Patch for On-Patch Detection of Molecules in Dermal Interstitial Fluid

• DOI: 10.1021/acssensors.9b00258
• Publication Date: 2019-05-09T13:52:13Z
• Authors: Chandana Kolluru; Rohit Gupta; Qisheng Jiang; Mikayla Williams; Hamed Gholami Derami; Sisi Cao; Richard K. Noel; Srikanth Singamaneni; Mark R. Prausnitz
• Keywords: Rhodamine 6G; Skin patch; Nanorod; Interstitial fluid; Surface-Enhanced Raman Spectroscopy

Minimally invasive devices to detect molecules in dermal interstitial fluid (ISF) are desirable for point-of-care diagnostic and monitoring applications. In this study, we developed a microneedle (MN) patch that collects ISF on-patch biomarker analysis by surface-enhanced Raman scattering (SERS). The micrometer-scale MNs create micropores the skin surface, through which microliter quantities of collected onto plasmonic paper on backing. was prepared immobilizing poly(styrenesulfonate) (PSS) coated gold nanorods (AuNRs) thin strip filter using calligraphy. Negatively charged PSS used bind positively rhodamine 6G (R6G), served as model compound, thereby localize R6G AuNR surface. bound surface detected quantified acquiring SERS spectra from MN patch. This approach measure pharmacokinetic profiles serum rats vivo. proof-of-concept study indicates has potential enable measurement research future medical