Solvent-less Dehydrogenative C–H Etherification with Alcohols Using Mechanochemistry

• DOI: 10.1021/acssuschemeng.0c08201
• Publication Date: 2021-03-09T16:56:55Z
• Authors: Kun Zhou; Hong-Yan Hao; Yang-Jie Mao; Qiu-Zi Wu; Lei Chen; Shuang Wang; Wu Jin; Zhen-Yuan Xu; Shao-Jie Lou; Dan-Qian Xu
• Keywords: Mechanochemistry; Primary (astronomy)

The aromatic C–H bond etherification with alcohols is one of the most atom-efficient ways to construct aryl ethers. However, it often requires a large excess as reagents, which limits substrate scope (especially for valuable alcohols). Herein, an alternative mechanochemical oximes diverse primary and secondary was developed first time. Given solvent-less condition ball milling technique, amount used in this chemistry has been significantly reduced (1.5–3.0 equiv substrates), thus enabling incorporation wide range present protocol enhances application prospect cross dehydrogenative strategy late-stage synthesis complex