One-Pot Construction of Functional Mesoporous Silica Nanoparticles for the Tumor-Acidity-Activated Synergistic Chemotherapy of Glioblastoma

• DOI: 10.1021/am402082d
• Publication Date: 2013-07-19T19:17:03Z
• Authors: Ze-Yong Li; Yun Liu; Xiao-Qiang Wang; Li-Han Liu; Jing-Jing Hu; Guo-Feng Luo; Wei-Hai Chen; Lei Rong; Xian-Zheng Zhang
• Keywords: Camptothecin; Hydrazone

Mesoporous silica nanoparticles (MSNs) have proved to be an effective carrier for controlled drug release and can functionalized easily use as stimuli-responsive vehicles. Here, a novel intelligent drug-delivery system (DDS), camptothecin (CPT)-loaded doxorubicin (DOX)-conjugated MSN (CPT@MSN-hyd-DOX), is reported via facile one-pot preparation in synergistic chemotherapy of glioblastoma. DOX was conjugated MSNs acid-labile hydrazone bonds, CPT loaded the pores MSNs. At pH 6.5 (analogous tumor tissues), fast observed that attributed hydrolysis bonds. In addition, further burst found at 5.0 lyso/endosomes cells), leading strong effect. all, could delivered simultaneously into cells, this DDS has great potential tumor-trigged tumors.