The Role of Surface Functionality in Determining Nanoparticle Cytotoxicity

• DOI: 10.1021/ar3000647
• Publication Date: 2013-01-07T14:19:39Z
• Authors: Sung Tae Kim; Krishnendu Saha; Chaekyu Kim; Vincent M. Rotello
• Keywords: Nanomaterials; Surface Modification; Biocompatibility; Surface charge; Biomolecule

Surface properties dictate the behavior of nanomaterials in vitro, vivo, and environment. Such include surface charge hydrophobicity. Also key are more complex supramolecular interactions such as aromatic stacking hydrogen bonding, even topology from structural to atomic level. functionalization nanoparticles (NPs) provides an effective way control interface between biological systems they designed interact with. In medicine, for instance, proper can maximize therapeutic or imaging efficacy while minimizing unfavorable side effects. Meanwhile, environmental science, thoughtful choice particle coating minimize impact manufactured on environment.A thorough knowledge how NP surfaces with various affect is essential creating NPs useful low toxicity, stability, biocompatibility, favorable distribution throughout cells tissues, pharmacokinetic profiles—and reducing potential nanomaterials, which becoming increasingly prominent marketplace.In this Account, we discuss our research that others into biomolecules at many scales, including role plays determining vivo nanomaterials. These be benign, beneficial, lead dysfunction proteins, genes cells, resulting cytotoxic genotoxic responses. Understanding these their consequences helps us design minimally invasive delivery agents.We also highlight Account have fabricated act agents via tailored biomacromolecules. particles offer new directions traditional small molecule therapies, potentially greater versatility than possible proteins nucleic acids.