Synthesis and Partial Characterization of Hydrogels Obtained via Glutaraldehyde Crosslinking of Acetylated Chitosan and of Hyaluronan Derivatives

• DOI: 10.1021/bm0340669
• Publication Date: 2003-07-14T04:47:55Z
• Authors: Vittorio Crescenzi; Andrea Francescan...; Anna Taglienti; Donatella Capitani; Luisa Mannina
• Keywords: Glutaraldehyde; Glyoxal

Hydrophilic networks based on functionalized hyaluronic acid and partially acetylated chitosan, respectively, have been obtained. In the case of (HA), primary amino functionalities introduced along polysaccharide chains. The ensuing derivatives, i.e., HA-lysine (HA-K), HA-diamino pentane (HA-DAP), HA-glycine-lysine (HA-GK), characterized by high field NMR spectroscopy. 2D-DOSY experiments allowed us to optimize purification procedure. Chitosan was made soluble in water partial acetylation. Cross-linking reactions performed using glutaraldehyde. obtained qualitatively means 13C CP-MAS technique. hydrogels also terms uptake.