Role of the Relative Molecular Length of the Components in Ternary Inclusion Crystals in the Chiral Recognition and Assembly of Supramolecular Helical Architectures

• DOI: 10.1021/cg060849c
• Publication Date: 2007-04-11T12:01:02Z
• Authors: Koichi Kodama; Yuka Kobayashi; Kazuhiko Saigo
• Keywords: Enantiopure drug; Molecular Recognition; Benzoic acid; Chirality

The systematic investigation of supramolecular host systems consisting a primary amine/carboxylic acids has been performed upon changing the molecular length component. combinations enantiopure erythro-2-amino-1,2-diphenylethanol (1) and achiral benzoic acid derivatives (2a−e) were found to be effective for inclusion 1-phenylethanol (3a−d) with chiral recognition. X-ray crystallographic analyses revealed that one-dimensional (1D) helical columnar architecture was commonly constructed in ternary crystals. However, there two types arrangements columns, anti-parallel parallel, depending on relative 2/3. Similarity lengths between 2 3 resulted an alignment while parallel achieved when one components much longer than other; 1D columns tend align manner cancel their dipole; however, switches avoid formation large voids columns.