Is Simpler Better? Synthetic Nicotinamide Cofactor Analogues for Redox Chemistry

• DOI: 10.1021/cs4011056
• Publication Date: 2014-01-22T19:05:28Z
• Authors: Caroline E. Paul; Isabel W. C. E. A...; Frank Hollmann
• Keywords: Biocatalysis; Moiety; Enzyme Catalysis; Amide; Alkene

The topic of synthetic nicotinamide cofactor analogues is resurfacing as new approaches are being explored, especially in the areas organic chemistry and biocatalysis. By changing adenine dinucleotide moiety for a simpler alkyl or aryl group taking advantage their ability hydride transfer, these biomimetics used redox reactions catalytic stoichiometric amounts. Alteration amide functional on pyridine ring, thus varying electronic properties, presence divalent metal ions also enable rate acceleration enzyme-catalyzed chemical reactions. Herein, an overview synthesis, mechanism, applications NAD(P)H chemistry, particularly 1,4-dihydronicotinamide derivatives oxidized counterpart, presented. These compounds have been extensively studied models enzymatic with oxidoreductases well nonenzymatic reactions, focus this review placed mainly scope limitations