Exploration of Oxidative Stress and Inflammatory Markers in Relation to Urinary Phthalate Metabolites: NHANES 1999–2006

• DOI: 10.1021/es202340b
• Publication Date: 2011-11-15T17:32:16Z
• Authors: Kelly K. Ferguson; Rita Loch-Caruso; John D. Meeker
• Keywords: Dibutyl phthalate

Phthalate exposure has been associated with a wide range of adverse health outcomes in limited epidemiologic studies, and inflammation oxidative stress have hypothesized as potential mechanisms involved. In the present study we investigated associations between urinary concentrations phthalate metabolites blood markers (bilirubin) (alkaline phosphatase [ALP], absolute neutrophil count [ANC], ferritin [adjusted for iron status], fibrinogen), using data from 10,026 participants National Health Nutrition Examination Survey (NHANES) recruited 1999 2006. After adjustment covariates found that bilirubin was inversely several (all p-values <0.0001), including di-2-ethylhexyl (DEHP) dibutyl (DBP), addition to monobenzyl (MBzP) mono-(3-carboxypropyl) (MCPP). Since is potent antioxidant these relationships suggest phthalates may be increased stress. Many same were also significantly positively related ANC, ALP, ferritin, suggesting inflammation. These useful other studies low-dose environmental contaminants.