Zn2+-Selective Switch of Duplex to Hairpin DNA

• DOI: 10.1021/ic503074p
• Publication Date: 2015-03-09T13:54:36Z
• Authors: Stephanie A. Sander; Alexandra K. Van ...; Janet R. Morrow
• Keywords: Duplex (building); Molecular switch

DNA sequences that undergo large changes in secondary structure upon binding of small molecules are the basis for molecular switches. Here we report a Zn2+ complex promotes conversion fully complementary double helix into hairpins. The conformational switch is promoted by an isolated or free ZnCl2 and macrocyclic ligand. selective over biologically relevant transition-metal ions including Cu2+ Fe2+. dual ligand/DNA approach may improve selectivity metal-ion-sensing applications.