Self-Association of Ruthenium(II) Polypyridyl Complexes and Their Interactions with Calf Thymus DNA

• DOI: 10.1021/ic902374t
• Publication Date: 2010-05-11T16:41:05Z
• Authors: Satish S. Bhat; Avinash S. Kumbhar; Peter Lönnecke; Evamarie Hey-Hawkins
• Keywords: Phenazine; Quinoxaline; Bipyridine; Proton NMR

Complexes of the type [Ru(N-N)(2)(bxbg)]Cl(2) where N-N is 2,2'-bipyridine (bpy) (1), 1,10-phenanthroline (phen) (2), dipyrido [3,2-d:2',3f] quinoxaline (dpq) (3), and dipyrido[3,2-a:2',3'-c]phenazine (dppz) (4) which incorporate bis(o-xylene)bipyridine glycoluril (bxbg) as ancillary ligand have been synthesized characterized by IR, NMR, UV-visible, luminescence, ESI-MS, cyclic voltammetry, spectroelectrochemistry. The initiates a head to association act nucleation point for further growth in two direction head-to-head tail-to-tail self-association resulting formation aggregates water investigated (1)H NOESY, steady state luminescence dilution experiments, electron microscopy studies. has confirmed single crystal X-ray analysis complex 2. Electrochemical spectroelectrochemical studies acetonitrile show that these complexes undergo reversible one oxidation from Ru(II) Ru(III). binding with calf thymus DNA (CT-DNA) studied absorption titration, steady-state time-resolved emission measurement investigate influence ligand. ability dependent on planarity intercalative polypyridyl affected