Albumin-Conjugated Corrole Metal Complexes: Extremely Simple Yet Very Efficient Biomimetic Oxidation Systems

• DOI: 10.1021/ja045372c
• Publication Date: 2005-03-02T05:37:33Z
• Authors: Atif Mahammed; Zeev Gross
• Keywords: Corrole; Peroxide

An extremely simple biomimetic oxidation system, consisting of mixing metal complexes amphiphilic corroles with serum albumins, utilizes hydrogen peroxide for asymmetric sulfoxidation in up to 74% ee. The albumin-conjugated manganese also display catalase-like activity, and mechanistic evidence points toward oxidant-coordinated manganese(III) as the prime reaction intermediate.