Direct Catalytic Anti-Markovnikov Hydroetherification of Alkenols

• DOI: 10.1021/ja309635w
• Publication Date: 2012-10-31T14:47:33Z
• Authors: David S. Hamilton; David A. Nicewicz
• Keywords: Markovnikov's rule

A direct intramolecular anti-Markovnikov hydroetherification reaction of alkenols is described. By employing catalytic quantities commercially available 9-mesityl-10-methylacridinium perchlorate and 2-phenylmalononitrile as a redox-cycling source H-atom, we report the alkenes with complete regioselectivity. In addition, present results demonstrating that this novel system can be applied to hydrolactonization alkenoic acids.