Catalytic Hydrotrifluoromethylation of Unactivated Alkenes

• DOI: 10.1021/ja401022x
• Publication Date: 2013-02-01T18:59:03Z
• Authors: Satoshi Mizuta; Stefan Verhoog; Keary M. Engle; Tanatorn Khotaviv...; Miriam O’Duill; Katherine Wheelhouse; Gerasimos Rassias; Maurice Médebielle; Véronique Gouverneur
• Keywords: Molecular Structure; [CHIM.ORGA]Chemical Sciences/Organic chemistry; Fluorine; Alkenes; [CHIM.ORGA] Chemical Sciences/Organic chemistry; Methylation; 01 natural sciences; Catalysis; 0104 chemical sciences

A visible-light-mediated hydrotrifluoromethylation of unactivated alkenes that uses the Umemoto reagent as the CF(3) source and MeOH as the reductant is disclosed. This effective transformation operates at room temperature in the presence of 5 mol % Ru(bpy)(3)Cl(2); the process is characterized by its operational simplicity and functional group tolerance.