Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry

• DOI: 10.1021/ja402586c
• Publication Date: 2013-06-03T17:19:53Z
• Authors: Jianwei Li; Piotr Nowak; Sijbren Otto
• Keywords: Molecular machine; Molecular Recognition

Dynamic combinatorial chemistry (DCC) is a subset of where the library members interconvert continuously by exchanging building blocks with each other. libraries (DCLs) are powerful tools for discovering unexpected and have given rise to many fascinating molecules, ranging from interlocked structures self-replicators. Furthermore, dynamic molecular networks can produce emergent properties at systems level, which provide exciting new opportunities in chemistry. In this perspective we will highlight some methodologies field analyze selected examples DCLs that under thermodynamic control, leading synthetic receptors, catalytic systems, complex self-assembled supramolecular architectures. Also reviewed extensions principles DCC not equilibrium may therefore harbor richer functional behavior. Examples include self-replication machines.