Protein-Mimetic, Molecularly Imprinted Nanoparticles for Selective Binding of Bile Salt Derivatives in Water

• DOI: 10.1021/ja406089c
• Publication Date: 2013-08-09T15:46:12Z
• Authors: Joseph K. Awino; Yan Zhao
• Keywords: Surface Modification; Derivative (finance); Linker

A tripropargylammonium surfactant with a methacrylate-terminated hydrophobic tail was combined bile salt derivative, divinyl benzene (DVB), and photo-cross-linker above its critical micelle concentration (CMC). Surface-cross-linking diazide, surface-functionalization an azido sugar free-radical-core-cross-linking under UV irradiation yielded molecularly imprinted nanoparticles (MINPs) template-specific binding pockets. The MINPs resemble protein receptors in size, complete water-solubility, tailored sites their cores. Strong selective of derivatives obtained, depending on the cross-linking density system.