A Peptoid “Antibody Surrogate” That Antagonizes VEGF Receptor 2 Activity

• DOI: 10.1021/ja711193x
• Publication Date: 2008-04-03T15:14:34Z
• Authors: D. Gomika Udugama...; Sean P. Dineen; Rolf A. Brekken; Thomas Kodadek
• Keywords: Peptoid; Peptidomimetic

We report a two-color, cell-based screen to identify specific receptor-binding compounds in combinatorial library of peptoids displayed on beads. apply this strategy the isolation vascular endothelial growth factor receptor 2 (VEGFR2)-binding peptoids. A dimeric derivative one these lead is shown be an antagonist VEGFR2 activity both vitro and vivo. This methodology provides potentially general route synthetic molecules that bind integral membrane receptors with affinities specificities similar those antibodies, but which are far smaller easier make manipulate.