A Microfluidic High-Resolution NMR Flow Probe

• DOI: 10.1021/ja900389x
• Publication Date: 2009-03-25T19:14:13Z
• Authors: Jacob Bart; Ard J. Kolkman; Anna Jo Oosthoek-...; Kaspar Koch; Pieter J. Nieuwland; Hans (J. W. G.) J...; Jan (P. J. M.) va...; Kirsten A. M. Ampt; Floris P. J. T. R...; Sybren S. Wijmenga; Han (J. G. E.) Ga...; Arno P. M. Kentgens
• Keywords: Microreactor

A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool invaluable for the in situ monitoring of reactions performed microreactors. As an example, acetylation benzyl alcohol with acetyl chloride was monitored. Because uncompromised (sub-Hz) resolution, this holds great promise metabolomics studies, as shown by analysis 600 nL human cerebrospinal fluid.