Diarylprolinol Silyl Ether Salts as New, Efficient, Water-Soluble, and Recyclable Organocatalysts for the Asymmetric Michael Addition on Water

• DOI: 10.1021/ja9093583
• Publication Date: 2009-12-15T15:18:35Z
• Authors: Zilong Zheng; Benjamin L. Perkins; Bukuo Ni
• Keywords: Michael reaction; Silyl ether; Addition reaction

A novel strategy for the catalytic asymmetric Michael addition of aldehydes to nitroolefins on water has been developed and provided adducts in excellent diastereo- enantioselectivities. notable feature these organocatalysts is that they can be recycled more than six times without a significant loss activity stereochemical control. In addition, synthetic procedure presented simple, practical, environmentally benign.