Alkyltriflones in the Ramberg–Bäcklund Reaction: An Efficient and Modular Synthesis of gem-Difluoroalkenes

• DOI: 10.1021/jacs.0c07924
• Publication Date: 2020-08-16T16:47:13Z
• Authors: Yuuki Maekawa; Masakazu Nambo; Daisuke Yokogawa; Cathleen M. Crudden
• Keywords: Base (topology)

The unprecedented synthesis of gem-difluoroalkenes through the Ramberg–Bäcklund reaction alkyl triflones is described herein. Structurally diverse, fully substituted that are difficult to prepare by other methods can be easily prepared from readily available treatment with specific Grignard reagents. Experimental and computational studies provide insight into unique critical role reagent, which serves both as a base remove α-proton Lewis acid assist C–F bond activation.