Defect Engineering Enables Synergistic Action of Enzyme-Mimicking Active Centers for High-Efficiency Tumor Therapy

• DOI: 10.1021/jacs.1c03510
• Publication Date: 2021-06-04T20:28:08Z
• Authors: Bin Yu; Wei Wang; Wenbo Sun; Chunhuan Jiang; Lehui Lu
• Keywords: Molybdenum; Iron; Lasers; Neoplasms; Humans; Oxides; 02 engineering and technology; Particle Size; 0210 nano-technology; Oxidation-Reduction; 3. Good health

Perusing redox nanozymes capable of disrupting cellular homeostasis offers new opportunities to develop cancer-specific therapy, but remains challenging, because most artificial enzymes lack enzyme-like scale and configuration. Herein, for the first time, we leverage a defect engineering strategy simple yet efficient nanozyme by constructing enzyme-mimicking active centers investigated its formation catalysis mechanism thoroughly. Specifically, partial Fe doping in MoOx (donated as Fe-MoOv) was demonstrated activate structure reconstruction with abundant site generation, including substitution oxygen vacancy (OV) defects, which significantly enable binding capacity catalytic activity Fe-MoOv synergetic fashion. More intriguingly, plenty delocalized electrons appear due Fe-facilitated band reconstruction, directly contributing remarkable surface plasmon resonance effect near-infrared (NIR) region. Under NIR-II laser irradiation, designed are able induce substantial disruption metabolism tumor region via cascade reactions, thus augmenting therapeutic effects. This study that takes advantage insights into developing high-efficiency nanozymes.