A Diastereodivergent and Enantioselective Approach to syn- and anti-Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines That Furnish Allylic Amines
Aza Compounds
Heterocyclic Compounds
Molecular Conformation
Stereoisomerism
Imines
Diamines
Oxidation-Reduction
01 natural sciences
Catalysis
Copper
0104 chemical sciences
DOI:
10.1021/jacs.1c07707
Publication Date:
2021-08-23T16:23:26Z
AUTHORS (3)
ABSTRACT
We introduce a new reagent class, 2-azatrienes, as a platform for catalytic enantioselective synthesis of allylic amines. Herein, we demonstrate their promise by diasteredivergent and enantioselective synthesis of syn- and anti-1,2-diamines by Cu-bis(phosphine)-catalyzed reductive couplings with imines. With Ph-BPE, anti-diamines are obtained, and with the rarely utilized t-Bu-BDPP, syn-diamines are generated.
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