Late-Stage Diversification: A Motivating Force in Organic Synthesis

• DOI: 10.1021/jacs.1c08920
• Publication Date: 2021-10-07T04:42:05Z
• Authors: Kelly E. Kim; Alexia N. Kim; Carter J. McCormick; Brian M. Stoltz
• Keywords: Natural product; Popularity

Interest in therapeutic discovery typically drives the preparation of natural product analogs, but these undertakings contribute significant advances for synthetic chemistry as well. The need a highly efficient and scalable route to complex molecular scaffold diversification frequently inspires new methodological development or unique application existing methods on structurally intricate systems. Additionally, planning with an aim toward late-stage can provide access otherwise unavailable compounds facilitate molecules diverse patterns substitution around shared carbon framework. For reasons among others, programs dedicated frameworks other scaffolds have been increasing popularity, trend likely continue given their fruitfulness breadth impact. In this Perspective, we discuss our experience using guiding principle synthesis analogs reflect impact such efforts future molecule synthesis.