Radical S-Adenosyl Methionine Enzyme BlsE Catalyzes a Radical-Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S

• DOI: 10.1021/jacs.1c12010
• Publication Date: 2022-03-03T12:41:30Z
• Authors: Yu-Hsuan Lee; Xueli Hou; Ridao Chen; Jianqiang Feng; Xiao Liu; Mark W. Ruszczycky; Jin-Ming Gao; Binju Wang; Jiahai Zhou; Hung-wen Liu
• Keywords: 0301 basic medicine; Adenosylmethionine Decarboxylase; S-Adenosylmethionine; 03 medical and health sciences; Dehydration; Humans; Nucleosides

The biosynthesis of blasticidin S has drawn attention due to the participation radical