Dual Hydrazine-Equipped Turn-On Manganese-Based Probes for Magnetic Resonance Imaging of Liver Fibrogenesis

• DOI: 10.1021/jacs.2c06231
• Publication Date: 2022-08-23T23:19:16Z
• Authors: Yingying Ning; Iris Yuwen Zhou; Nicholas J. Rotile; Pamela Pantazopoulos; Huan Wang; Stephen Cole Barrett; Mozhdeh Sojoodi; Kenneth K. Tanabe; Peter Caravan
• Keywords: Hydrazine (antidepressant); Turn (biochemistry)

Liver fibrogenesis is accompanied by upregulation of lysyl oxidase enzymes, which catalyze oxidation lysine ε-amino groups on the extracellular matrix proteins to form aldehyde containing amino acid allysine (Lys