Conversion of Aryl Azides to Aminopyridines

• DOI: 10.1021/jacs.2c08464
• Publication Date: 2022-09-22T13:31:53Z
• Authors: Sajan C. Patel; Noah Z. Burns
• Keywords: Aminopyridines

A longstanding challenge in fundamental functional group interconversion has been the direct transformation of benzene into pyridine via nitrogen insertion and carbon deletion. Herein, we report a protocol for aryl azides, easily accessible from their corresponding anilines, to 2-aminopyridines using blue light oxygen. Mechanistic studies corroborate that arene conversion is achieved by ring followed oxidative extrusion.