Enantioselective Selenol-ene Using Rh-Hydride Catalysis

• DOI: 10.1021/jacs.2c08475
• Publication Date: 2022-09-26T21:11:56Z
• Authors: Hannah S. Slocumb; Shaozhen Nie; Vy M. Dong; Xiao-Hui Yang
• Keywords: Stereoisomerism; Selenium Compounds; 01 natural sciences; Catalysis; Styrenes; 0104 chemical sciences

This study showcases the first enantioselective hydroselenation of styrenes. Organoselenium building blocks are accessed with selectivity for the branched isomer. Through a Rh-hydride pathway, C-Se bonds can be forged with excellent regio- and enantiocontrol.