Redox-Controlled Shunts in a Synthetic Chemical Reaction Cycle

• DOI: 10.1021/jacs.3c00985
• Publication Date: 2023-04-24T12:01:22Z
• Authors: Anastasiia Sharko; Benjamin Spitzbarth; Thomas M. Hermans; Rienk Eelkema
• Keywords: Adaptability; Oxidation reduction

Shunts, alternative pathways in chemical reaction networks (CRNs), are ubiquitous nature, enabling adaptability to external and internal stimuli. We introduce a CRN which the recovery of Michael-accepting species is driven by oxidation chemistry. Using weak oxidants can enable access two shunts within this with different kinetics reduced number side reactions compared main cycle that strong oxidants. Furthermore, we strategy recycle one products under flow conditions partially reverse control product speciation throughout time. These findings new levels over artificial CRNs, redox chemistry, narrowing gap between synthetic natural systems.