A Radioluminescent Metal–Organic Framework for Monitoring 225Ac in Vivo

• DOI: 10.1021/jacs.3c02325
• Publication Date: 2023-06-27T08:25:30Z
• Authors: Yugang Zhang; Feize Li; Zhencun Cui; Kai Li; Jingwen Guan; Longlong Tian; Yaxing Wang; Ning Liu; Wangsuo Wu; Zhifang Chai; Shuao Wang
• Keywords: Biodistribution; Radioluminescence; Europium

225Ac is considered as one of the most promising radioisotopes for alpha-therapy because its emitted high-energy α-particles can efficiently damage tumor cells. However, it also represents a significant threat to healthy tissues owing extremely high radiotoxicity if targeted therapy fails. This calls pressing requirement monitoring biodistribution in vivo during treatment tumors. lack imageable photons or positrons from therapeutic doses makes this task currently quite challenging. We report here nanoscale luminescent europium-organic framework (EuMOF) that allows fast, simple, and efficient labeling crystal structure with sufficient 225Ac-retention stability based on similar coordination behaviors between Ac3+ Eu3+. After labeling, short distance Eu3+ leads exceedingly energy transduction from225Ac-emitted surrounding ions, which emits red luminescence through scintillation process produces clearcut imaging. The intensity distribution radioluminescence signal originating 225Ac-labeled EuMOF consistent dose dispersed among various organs determined by radioanalytical measurement ex vivo, certifying feasibility directly using optical imaging first time. In addition, displays notable efficiency treating tumor. These results provide general design principle fabricating radiopharmaceuticals propose simple way track radionuclides no photons, including but not limited 225Ac.