Ru-NHC-Catalyzed Asymmetric, Complete Hydrogenation of Indoles and Benzofurans: One Catalyst with Dual Function

• DOI: 10.1021/jacs.3c04983
• Publication Date: 2023-07-12T12:01:05Z
• Authors: Fuhao Zhang; Himadri Sekhar Sa...; Constantin G. Dan...; Frank Glorius
• Keywords: Asymmetric hydrogenation; Homogeneous Catalysis; Dual role

The highly enantioselective and complete hydrogenation of protected indoles benzofurans has been developed, affording facile access to a range chiral three-dimensional octahydroindoles octahydrobenzofurans, which are prevalent in many bioactive molecules organocatalysts. Remarkably, we control the nature ruthenium N-heterocyclic carbene complex employed as both homogeneous heterogeneous catalysts, providing new avenues for its potential applications asymmetric more challenging aromatic compounds.