Cyclodextrin Incorporation into Covalent Organic Frameworks Enables Extensive Liquid and Gas Chromatographic Enantioseparations

• DOI: 10.1021/jacs.3c05973
• Publication Date: 2023-08-19T03:55:15Z
• Authors: Chen Yuan; Zhen Wang; Wanqi Xiong; Zhifeng Huang; Yalin Lai; Shiguo Fu; Jinqiao Dong; Aihong Duan; Xiandeng Hou; Li-Ming Yuan; Yong Cui
• Keywords: Complex matrix; Matrix (chemical analysis)

The separation of enantiomers using high-performance chromatography technologies represents great importance and interest. In this aspect, β-cyclodextrin (β-CD) its derivatives have been extensively studied as chiral stationary phases (CSPs). Nevertheless, β-CD that was immobilized on a traditional matrix often exhibited low stabilities limited operating ranges. Recently, covalent organic frameworks (COFs) with highly ordered nanopores are emerging promising CSPs for enantioseparations, but their practical applications still hampered by the difficulty monomer COF synthesis. Herein, two β-CD-driven COFs synthesized via fast facile plasma-induced polymerization combined postsynthesis modification strategy. precisely defined channels enhanced accessibility accommodated to analytes acted robust protective barriers safeguard from harsh environments. Therefore, β-CD-modified can be potentially general extensive enantioseparation in both gas liquid chromatography, wide range racemates were separated. Compared commonly employed commercial columns, these COF-based columns comparable resolution capability superior application versatility. This work integrates advantages overcomes defects β-CD, thus advancing platforms selector giving promise chromatographic enantioseparation.