Polymer Vesicles with Integrated Photothermal Responsiveness

• DOI: 10.1021/jacs.3c07134
• Publication Date: 2023-09-04T09:15:14Z
• Authors: Yingtong Luo; Hanglong Wu; Xuan Zhou; Jianhong Wang; Süleyman Er; Yudong Li; Pascal L. W. Welzen; Roy A. J. F. Oerl...; Loai K. E. A. Abd...; Jingxin Shao; Jan C. M. van Hest
• Keywords: Photothermal effect; Biocompatibility; Polymersome

Functionalized polymer vesicles have been proven to be highly promising in biomedical applications due their good biocompatibility, easy processability, and multifunctional responsive capacities. However, photothermal-responsive triggered by near-infrared (NIR) light not widely reported until now. Herein, we propose a new strategy for designing NIR light-mediated photothermal vesicles. A small molecule (PTA) with NIR-triggered features was synthesized combining D-D′-A-D′-D configuration framework molecular rotor function (TPE). The feasibility of the design demonstrated through density functional theory calculations. PTA moieties were introduced hydrophobic segment poly(ethylene glycol)-poly(trimethylene carbonate) block copolymer, which carbonate monomers modified side chain an active ester group. amphiphilic copolymers (PEG44-PTA2) then used as building blocks self-assembly class functionalized inherited NIR-mediated high performance agent (PTA). After laser irradiation 10 min, temperature PTA-Ps aqueous solution raised 56 °C. properties bilayer structure after still intact, that they could applied robust platform therapy. Besides performance, loading capacity investigated well. Hydrophobic cargo (Cy7) hydrophilic (Sulfo-Cy5) successfully encapsulated PTA-Ps. These make this interesting synergistic therapy anticancer treatment.