Enzymatic Nitrogen Incorporation Using Hydroxylamine

• DOI: 10.1021/jacs.3c08053
• Publication Date: 2023-09-06T13:08:16Z
• Authors: Shilong Gao; Anuvab Das; Edwin Alfonzo; Kathleen M. Sicinski; Dominic Rieger; Frances H. Arnold
• Keywords: Hydroxylamine; Nitrene; Biocatalysis

Hydroxylamine-derived reagents have enabled versatile nitrene transfer reactions for introducing nitrogen-containing functionalities in small-molecule catalysis, as well biocatalysis. These reagents, however, result a poor atom economy and stoichiometric organic waste. Activating hydroxylamine (NH