Chiral Covalent Organic Cages: Structural Isomerism and Enantioselective Catalysis

• DOI: 10.1021/jacs.3c12555
• Publication Date: 2024-02-28T09:44:48Z
• Authors: Kaixuan Wang; Xianhui Tang; Bai Amutha Anjali; Jinqiao Dong; Jianwen Jiang; Yan Liu; Yong Cui
• Keywords: Imine; Dynamic Covalent Chemistry

Covalent organic cages are a prominent class of discrete porous architectures; however, their structural isomerism remains relatively unexplored. Here, we demonstrate the chiral covalent that renders distinct enantioselective catalytic properties. Imine condensations tetra-topic 5,10-di(3,5-diformylphenyl)-5,10-dihydrophenazine and ditopic 1,2-cyclohexanediamine produce two [4 + 8] cage isomers with totally different topologies geometries depend on orientations four tetraaldehyde units respect to each other. One isomer (