Late-Stage Saturation of Drug Molecules

• DOI: 10.1021/jacs.4c00807
• Publication Date: 2024-04-15T23:44:26Z
• Authors: De-Hai Liu; Philipp M. Pflüger; Andrew Outlaw; Lukas Lückemeier; Fuhao Zhang; Clinton Regan; Hamid Rashidi Nodeh; Tim Cernak; Jiajia Ma; Frank Glorius
• Keywords: Chemical space; Saturation (graph theory)

The available methods of chemical synthesis have arguably contributed to the prevalence aromatic rings, such as benzene, toluene, xylene, or pyridine, in modern pharmaceuticals. Many sp